The two clubs face off at the MCG on Saturday at 7.40pm.
Five players are missing from Collingwood’s team.
One player is still recovering after a vehicle accident left him unconscious in training.
North Melbourne’s second‑tier squad beat North’s youngsters last week by 43 points.
That win has provided the seniors boosted morale.
The two sides want a positive kickoff to the latter half of the season.