Miguel Díaz-Canel spoke to crowds in Havana the US is trying to undermine Cuba’s political system.
He declared Washington wants total control through the island.
Díaz-Canel branded American policies a type of political genocide during July 26 events.
He emphasised this is a menace to the country's right to govern.
Raúl Castro did not attend from the main rally.
Tensions are elevated due to sanctions and US political pressure.